Killer cell immunoglobulin-like receptor ligand matching and outcomes after unrelated cord blood transplantation acute myeloid leukemia
Identifieur interne : 001C09 ( Main/Exploration ); précédent : 001C08; suivant : 001C10Killer cell immunoglobulin-like receptor ligand matching and outcomes after unrelated cord blood transplantation acute myeloid leukemia
Auteurs : Vanderson Rocha [France, Royaume-Uni] ; Annalisa Ruggeri [France] ; Stephen Spellman [États-Unis] ; Tao Wang [États-Unis] ; Ronald Sobecks [États-Unis] ; Franco Locatelli [Italie] ; Medhat Askar [États-Unis] ; Gerard Michel [France] ; William Arcese [Italie] ; Anna Paola Iori [Italie] ; Duncan Purtill [Australie] ; Robert Danby [Royaume-Uni] ; Guillermo F. Sanz [Espagne] ; Eliane Gluckman [France, Monaco] ; Mary Eapen [États-Unis]Source :
- Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation [ 1083-8791 ] ; 2016.
Abstract
The effect of killer-cell immunoglobulin-like receptor (KIR)-ligand matching on outcomes after unrelated cord blood (CB) transplantation was studied in patients with acute myeloid leukemia (AML; n=461), categorizing KIR-ligand for HLA-C groups C1 and C2, and Bw4. Donor-recipient HLA-matching considered allele-level matching at HLA-A, -B, -C and –DRB1. Separate analyses were conducted for 6–7/8 HLA-matched and 3–5/8 HLA-matched transplants as HLA-matching confounded KIR-ligand matching (i.e., KIR-ligand mismatching was less likely with better HLA-matching). All patients received single CB unit and myeloablative conditioning. There were no significant differences in non-relapse mortality (NRM), relapse and overall mortality by KIR ligand match status. But, among recipients of 3–5/8 HLA-matched transplants, NRM (HR 2.26, p=0.008) and overall mortality (HR 1.78, p=0.008) but not relapse were higher with KIR-ligand mismatched (host vs. graft [HVG] direction) compared to KIR ligand-matched transplants. These data do not support selecting CB units based on KIR ligand match status for transplants mismatched at 1 or 2 HLA loci. Although transplants mismatched at 3 or more HLA-loci are not recommended avoiding KIR ligand mismatching in this setting lowers mortality risks.
Url:
DOI: 10.1016/j.bbmt.2016.04.007
PubMed: 27090957
PubMed Central: 4915071
Affiliations:
- Australie, Espagne, France, Italie, Monaco, Royaume-Uni, États-Unis
- Angleterre, Latium, Minnesota, Ohio, Oxfordshire, Provence-Alpes-Côte d'Azur, Texas, Wisconsin, Île-de-France
- Marseille, Oxford, Paris, Rome
- Université d'Oxford
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type="city">Paris</settlement></placeName></affiliation><affiliation wicri:level="4"><nlm:aff id="A2">Churchill Hospital and NHSBT, University of Oxford, Oxford, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Churchill Hospital and NHSBT, University of Oxford, Oxford</wicri:regionArea><placeName><settlement type="city">Oxford</settlement><region type="country">Angleterre</region><region type="comté" nuts="2">Oxfordshire</region><settlement type="city">Oxford</settlement></placeName><orgName type="university">Université d'Oxford</orgName></affiliation></author><author><name sortKey="Ruggeri, Annalisa" sort="Ruggeri, Annalisa" uniqKey="Ruggeri A" first="Annalisa" last="Ruggeri">Annalisa Ruggeri</name><affiliation wicri:level="3"><nlm:aff id="A1">Eurocord, Hôpital Saint Louis, Paris, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Eurocord, Hôpital Saint Louis, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="A3">Service d’Hematologie et therapie cellulaire, Hôpital Saint Antoine, Paris, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Service d’Hematologie et therapie cellulaire, Hôpital Saint Antoine, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Spellman, Stephen" sort="Spellman, Stephen" uniqKey="Spellman S" first="Stephen" last="Spellman">Stephen Spellman</name><affiliation wicri:level="2"><nlm:aff id="A4">Center for International Blood and Marrow Transplant Research, National Marrow Donor Program, Minneapolis, MN, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Center for International Blood and Marrow Transplant Research, National Marrow Donor Program, Minneapolis, MN</wicri:regionArea><placeName><region type="state">Minnesota</region></placeName></affiliation></author><author><name sortKey="Wang, Tao" sort="Wang, Tao" uniqKey="Wang T" first="Tao" last="Wang">Tao Wang</name><affiliation wicri:level="2"><nlm:aff id="A5">Division of Biostatistics Medical College of Wisconsin, Milwaukee, WI, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Division of Biostatistics Medical College of Wisconsin, Milwaukee, WI</wicri:regionArea><placeName><region type="state">Wisconsin</region></placeName></affiliation></author><author><name sortKey="Sobecks, Ronald" sort="Sobecks, Ronald" uniqKey="Sobecks R" first="Ronald" last="Sobecks">Ronald Sobecks</name><affiliation wicri:level="2"><nlm:aff id="A6">Department of Hematology and Medical Oncology, Taussig Cancer Institute, Cleveland Clinic, Cleveland, Ohio, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Hematology and Medical Oncology, Taussig Cancer Institute, Cleveland Clinic, Cleveland, Ohio</wicri:regionArea><placeName><region type="state">Ohio</region></placeName></affiliation></author><author><name sortKey="Locatelli, Franco" sort="Locatelli, Franco" uniqKey="Locatelli F" first="Franco" last="Locatelli">Franco Locatelli</name><affiliation wicri:level="1"><nlm:aff id="A7">IRCCS Ospedale Pediatrico Bambino Gesù, Rome and University of Pavia, Pavia, Italy</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>IRCCS Ospedale Pediatrico Bambino Gesù, Rome and University of Pavia, Pavia</wicri:regionArea><wicri:noRegion>Pavia</wicri:noRegion></affiliation></author><author><name sortKey="Askar, Medhat" sort="Askar, Medhat" uniqKey="Askar M" first="Medhat" last="Askar">Medhat Askar</name><affiliation wicri:level="2"><nlm:aff id="A8">Baylor University Medical Center, Dallas, TX, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Baylor University Medical Center, Dallas, TX</wicri:regionArea><placeName><region type="state">Texas</region></placeName></affiliation></author><author><name sortKey="Michel, Gerard" sort="Michel, Gerard" uniqKey="Michel G" first="Gerard" last="Michel">Gerard Michel</name><affiliation wicri:level="3"><nlm:aff id="A9">University Hospital of Marseille, Marseille, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>University Hospital of Marseille, Marseille</wicri:regionArea><placeName><region type="region">Provence-Alpes-Côte d'Azur</region><region type="old region">Provence-Alpes-Côte d'Azur</region><settlement type="city">Marseille</settlement></placeName></affiliation></author><author><name sortKey="Arcese, William" sort="Arcese, William" uniqKey="Arcese W" first="William" last="Arcese">William Arcese</name><affiliation wicri:level="3"><nlm:aff id="A10">Rome Transplant Network, University “Tor Vergata”, Rome, Italy</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Rome Transplant Network, University “Tor Vergata”, Rome</wicri:regionArea><placeName><settlement type="city">Rome</settlement><region nuts="2">Latium</region></placeName></affiliation></author><author><name sortKey="Iori, Anna Paola" sort="Iori, Anna Paola" uniqKey="Iori A" first="Anna Paola" last="Iori">Anna Paola Iori</name><affiliation wicri:level="3"><nlm:aff id="A11">University of Rome, La Sapienza, Rome, Italy</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>University of Rome, La Sapienza, Rome</wicri:regionArea><placeName><settlement type="city">Rome</settlement><region nuts="2">Latium</region></placeName></affiliation></author><author><name sortKey="Purtill, Duncan" sort="Purtill, Duncan" uniqKey="Purtill D" first="Duncan" last="Purtill">Duncan Purtill</name><affiliation wicri:level="1"><nlm:aff id="A12">Royal Perth Hospital, Perth, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Royal Perth Hospital, Perth</wicri:regionArea><wicri:noRegion>Perth</wicri:noRegion></affiliation></author><author><name sortKey="Danby, Robert" sort="Danby, Robert" uniqKey="Danby R" first="Robert" last="Danby">Robert Danby</name><affiliation wicri:level="4"><nlm:aff id="A2">Churchill Hospital and NHSBT, University of Oxford, Oxford, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Churchill Hospital and NHSBT, University of Oxford, Oxford</wicri:regionArea><placeName><settlement type="city">Oxford</settlement><region type="country">Angleterre</region><region type="comté" nuts="2">Oxfordshire</region><settlement type="city">Oxford</settlement></placeName><orgName type="university">Université d'Oxford</orgName></affiliation></author><author><name sortKey="Sanz, Guillermo F" sort="Sanz, Guillermo F" uniqKey="Sanz G" first="Guillermo F." last="Sanz">Guillermo F. Sanz</name><affiliation wicri:level="1"><nlm:aff id="A13">Hospital Universitario La Fe, Valencia, Spain</nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea>Hospital Universitario La Fe, Valencia</wicri:regionArea><wicri:noRegion>Valencia</wicri:noRegion></affiliation></author><author><name sortKey="Gluckman, Eliane" sort="Gluckman, Eliane" uniqKey="Gluckman E" first="Eliane" last="Gluckman">Eliane Gluckman</name><affiliation wicri:level="3"><nlm:aff id="A1">Eurocord, Hôpital Saint Louis, Paris, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Eurocord, Hôpital Saint Louis, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation><affiliation wicri:level="1"><nlm:aff id="A14">Monacord, Centre Scientifique de Monaco, Monaco</nlm:aff><country xml:lang="fr">Monaco</country><wicri:regionArea>Monacord, Centre Scientifique de Monaco</wicri:regionArea><wicri:noRegion>Centre Scientifique de Monaco</wicri:noRegion></affiliation></author><author><name sortKey="Eapen, Mary" sort="Eapen, Mary" uniqKey="Eapen M" first="Mary" last="Eapen">Mary Eapen</name><affiliation wicri:level="2"><nlm:aff id="A15">Department of Medicine, Medical College of Wisconsin, Milwaukee, WI, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Medicine, Medical College of Wisconsin, Milwaukee, WI</wicri:regionArea><placeName><region type="state">Wisconsin</region></placeName></affiliation></author></analytic><series><title level="j">Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation</title><idno type="ISSN">1083-8791</idno><idno type="eISSN">1523-6536</idno><imprint><date when="2016">2016</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p id="P1">The effect of killer-cell immunoglobulin-like receptor (KIR)-ligand matching on outcomes after unrelated cord blood (CB) transplantation was studied in patients with acute myeloid leukemia (AML; n=461), categorizing KIR-ligand for HLA-C groups C1 and C2, and Bw4. Donor-recipient HLA-matching considered allele-level matching at HLA-A, -B, -C and –DRB1. Separate analyses were conducted for 6–7/8 HLA-matched and 3–5/8 HLA-matched transplants as HLA-matching confounded KIR-ligand matching (i.e., KIR-ligand mismatching was less likely with better HLA-matching). All patients received single CB unit and myeloablative conditioning. There were no significant differences in non-relapse mortality (NRM), relapse and overall mortality by KIR ligand match status. But, among recipients of 3–5/8 HLA-matched transplants, NRM (HR 2.26, p=0.008) and overall mortality (HR 1.78, p=0.008) but not relapse were higher with KIR-ligand mismatched (host vs. graft [HVG] direction) compared to KIR ligand-matched transplants. These data do not support selecting CB units based on KIR ligand match status for transplants mismatched at 1 or 2 HLA loci. Although transplants mismatched at 3 or more HLA-loci are not recommended avoiding KIR ligand mismatching in this setting lowers mortality risks.</p></div></front></TEI><affiliations><list><country><li>Australie</li><li>Espagne</li><li>France</li><li>Italie</li><li>Monaco</li><li>Royaume-Uni</li><li>États-Unis</li></country><region><li>Angleterre</li><li>Latium</li><li>Minnesota</li><li>Ohio</li><li>Oxfordshire</li><li>Provence-Alpes-Côte d'Azur</li><li>Texas</li><li>Wisconsin</li><li>Île-de-France</li></region><settlement><li>Marseille</li><li>Oxford</li><li>Paris</li><li>Rome</li></settlement><orgName><li>Université d'Oxford</li></orgName></list><tree><country name="France"><region name="Île-de-France"><name sortKey="Rocha, Vanderson" sort="Rocha, Vanderson" uniqKey="Rocha V" first="Vanderson" last="Rocha">Vanderson Rocha</name></region><name sortKey="Gluckman, Eliane" sort="Gluckman, Eliane" uniqKey="Gluckman E" first="Eliane" last="Gluckman">Eliane Gluckman</name><name sortKey="Michel, Gerard" sort="Michel, Gerard" uniqKey="Michel G" first="Gerard" last="Michel">Gerard Michel</name><name sortKey="Ruggeri, Annalisa" sort="Ruggeri, Annalisa" uniqKey="Ruggeri A" first="Annalisa" last="Ruggeri">Annalisa Ruggeri</name><name sortKey="Ruggeri, Annalisa" sort="Ruggeri, Annalisa" uniqKey="Ruggeri A" first="Annalisa" last="Ruggeri">Annalisa Ruggeri</name></country><country name="Royaume-Uni"><region name="Angleterre"><name sortKey="Rocha, Vanderson" sort="Rocha, Vanderson" uniqKey="Rocha V" first="Vanderson" last="Rocha">Vanderson Rocha</name></region><name sortKey="Danby, Robert" sort="Danby, Robert" uniqKey="Danby R" first="Robert" last="Danby">Robert Danby</name></country><country name="États-Unis"><region name="Minnesota"><name sortKey="Spellman, Stephen" sort="Spellman, Stephen" uniqKey="Spellman S" first="Stephen" last="Spellman">Stephen Spellman</name></region><name sortKey="Askar, Medhat" sort="Askar, Medhat" uniqKey="Askar M" first="Medhat" last="Askar">Medhat Askar</name><name sortKey="Eapen, Mary" sort="Eapen, Mary" uniqKey="Eapen M" first="Mary" last="Eapen">Mary Eapen</name><name sortKey="Sobecks, Ronald" sort="Sobecks, Ronald" uniqKey="Sobecks R" first="Ronald" last="Sobecks">Ronald Sobecks</name><name sortKey="Wang, Tao" sort="Wang, Tao" uniqKey="Wang T" first="Tao" last="Wang">Tao Wang</name></country><country name="Italie"><noRegion><name sortKey="Locatelli, Franco" sort="Locatelli, Franco" uniqKey="Locatelli F" first="Franco" last="Locatelli">Franco Locatelli</name></noRegion><name sortKey="Arcese, William" sort="Arcese, William" uniqKey="Arcese W" first="William" last="Arcese">William Arcese</name><name sortKey="Iori, Anna Paola" sort="Iori, Anna Paola" uniqKey="Iori A" first="Anna Paola" last="Iori">Anna Paola Iori</name></country><country name="Australie"><noRegion><name sortKey="Purtill, Duncan" sort="Purtill, Duncan" uniqKey="Purtill D" first="Duncan" last="Purtill">Duncan Purtill</name></noRegion></country><country name="Espagne"><noRegion><name sortKey="Sanz, Guillermo F" sort="Sanz, Guillermo F" uniqKey="Sanz G" first="Guillermo F." last="Sanz">Guillermo F. Sanz</name></noRegion></country><country name="Monaco"><noRegion><name sortKey="Gluckman, Eliane" sort="Gluckman, Eliane" uniqKey="Gluckman E" first="Eliane" last="Gluckman">Eliane Gluckman</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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